4-3-3: Predicted Man United lineup to face Chelsea: Martial, Rashford and Rooney out

Mkhitaryan could lead the line for Manchester United

Manchester United will seek to avenge their 4-0 league defeat at the hands of Chelsea earlier in the season when they take on the Blues in the quarter-final of the FA Cup.

The Red Devils have lost just twice since their humbling at the Bridge back in October 2016, but their opposition still pose a huge threat owing to their excellent run which sees them top of the league.

Update: United will be without all four of their senior strikers as they head to west London for the crunch Cup tie. Wayne Rooney is said to have got injured while colliding with Phil Jones in training while trio Marcus Rashford, Anthony Martial and Zlatan Ibrahimovic are also ruled out with the latter serving a suspension.

Formation: 4-3-3

Jose Mourinho is likely to keep a solid base at the back versus his former club following an unpleasant return last time around.

Lineup:

David de Gea is expected to retain the number one role following a rest for the Europa League clash against Rostov in midweek.

Antonio Valencia has made the right-back role his own in recent seasons, and he will start in that position with Daley Blind likely to get the nod over Matteo Darmian and Luke Shaw for the left-back spot.

Phil Jones has been particularly awful in his past two outings against Bournemouth and Rostov, and he could be replaced by Eric Bailly who could partner Marcos Rojo at the heart of the defence.

With an injury crisis having resulted, Michael Carrick could be deployed as the lone holding midfielder with Ander Herrera and Marouane Fellaini getting the nod to feature alongside the veteran in a three-man midfield.

Henrikh Mkhitaryan netted the key away goal in the 1-1 scoreline in Rostov, and he could get a surprise start upfront with Paul Pogba on the left wing while Juan Mata could be deployed on the right side of the attack.

Ibrahimovic will serve the first of his three-game domestic ban on Monday night following an elbow on Tyrone Mings, and this has clearly affected the balance of the team with Rooney, Martial (both injury) and Rashford (illness) ruled out of the game.